From aspirin, to penicillin, to rapamycin, the natural world has been, and continues to be, a prolific source of medically relevant chemical starting points for groundbreaking therapeutics. Unfortunately, typical approaches in this field are plagued by long-timelines and sample complexity. Since 2012, Sirenas has been the pioneer and global leader in harnessing computational metabolomics for the discovery of small molecule therapeutic leads from natural sources. Our approach, dubbed ATLANTIS™, unleashes cutting-edge computational algorithms on large, proprietary metabolomic and bioassay datasets to rapidly uncover key chemical and biological insights for the small molecules present in complex samples from extremely biodiverse environments. The end result: the ability to mine a vastly untapped chemical language for new chemical scaffolds effective across a broad array of high value targets and disease models.
Over the last decade and working with experts and local communities, Sirenas has sustainably and ethically built one of the largest and most unique collections of marine organisms and plants from diverse ecosystems and geographies. From the deep sea to coral reefs and estuaries.
We’ve run these samples through cutting edge and proprietary chemical extraction and analytics, and tested each one in over 70 in-vitro biological assays relevant to human health.
The result is the largest repository of information connecting the unchartered chemistry of marine organisms to applications in human health. Our insights reveal both extracts and single compounds that modulate inflammation, pathways in cancer, infectious disease and microbiome dynamics.
We are now using these findings to help design the next generation of health products, to bring the untapped and limitless healing power of the ocean to you.